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DOI:10.1039/d4ra01812e - Corpus ID: 269836651
@article{Crossley2024DevelopmentOP, title={Development of phenyllactic acid ionic liquids and evaluation of cytotoxicity to human cervical epithelial cells}, author={Phoebe Crossley and Yogesh Sutar and Irina Tsoy and Srushti Mukkirwar and Paweł Łaniewski and Melissa M. Herbst-Kralovetz and Abhijit A. Date}, journal={RSC Advances}, year={2024}, volume={14}, pages={16083 - 16092}, url={https://api.semanticscholar.org/CorpusID:269836651}}
- Phoebe Crossley, Yogesh Sutar, Abhijit A. Date
- Published in RSC Advances 15 May 2024
- Medicine, Chemistry
It is successfully demonstrated that transforming PLA into ILs efficiently enhances its solubility in water and these formulations are not toxic to human epithelial cells.
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38 References
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Medicine, Environmental Science
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Findings indicate a key role for LA in future prophylactic strategies and assessed the impact of combined and individual SCFAs and LA on vagin*l epithelial cells grown in air–liquid interface cultures, finding LA was found to be the primary contributor of the beneficial effects.
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In vitro studies showed that Bx795-Doc-SNES retained the inherent antiviral activity against HSV-2 and showed similar in vitro cytocompatibility, indicating the availability of BX795 from the SNES in vitro.
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Both Bet6 and Carn6 have good potential as functional excipients, showing solubilising, stabilising, mucoadhesive, and antimicrobial properties; their in vitro cytotoxicity and in vivo ocular tolerability pave the way for their future use in ophthalmic applications.
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Medicine, Chemistry
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The review highlights the recent advancement and further applications of ionic liquids to deliver drugs in the pharmaceutical and biomedical fields.
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Medicine, Biology
mSphere
The study validated that vagin*l lactobacilli exhibit a close phylogenetic relationship and used untargeted metabolomics coupled with the 3D cervical epithelial cell model to identify metabolic differences among vagin*l Lactobacillus species and how those differences related to maintaining homeostasis of the cervical epithelium.
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Agricultural and Food Sciences
Journal of dairy science
Phenyllactic acid (PLA) has been demonstrated to possess antibacterial activity and capacity to prolong food shelf life. However, studies on the performance of PLA in inhibiting Staphylococcus aureus…
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Medicine, Biology
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It is demonstrated that 3D cervical epithelial cell colonized with cervicovagin*l microbiota faithfully reproduce the immunometabolic microenvironment previously observed in clinical studies and can successfully be used as a robust tool to evaluate host responses to commensal and pathogenic bacteria in the female reproductive tract.
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